TABLE 6.

Scoring of Masson trichrome staining and 7 immunohistochemical biomarkers in autopsy liver samples of 14 MUL patients and 6 control specimens

Marker	Central vein region		p	Portal space		p	Sinusoids		p
	MUL	Control		MUL	Control		MUL	Control
Trichrome	1.45 ± 0.57	0.31 ± 0.32	<.001	2.16 ± 0.53	1.07 ± 0.10	<.001	1.50 ± 0.66	0.28 ± 0.20	<.001
SMA	1.23 ± 0.38	1.02 ± 0.04	ns	1.43 ± 0.40	1.02 ± 0.04	.019	1.29 ± 0.43	1.14 ± 0.30	ns
Vimentin	0.37 ± 0.37	0.52 ± 0.26	ns	1.61 ± 0.81	1.06 ± 0.06	ns	1.25 ± 0.32	1.01 ± 0.03	ns
Collagen I	0.89 ± 0.41	1.00 ± 0.37	ns	1.62 ± 0.48	1.00 ± 0.00	.001	1.22 ± 0.51	0.54 ± 0.58	.033
CD34	0.60 ± 0.36	0.90 ± 0.09	.008	1.25 ± 0.29	1.01 ± 0.02	.004	1.21 ± 0.67	0.20 ± 0.15	<.001
CD68	0.49 ± 0.93	0.11 ± 0.11	ns	1.05 ± 0.82	1.06 ± 0.18	ns	1.53 ± 0.62	1.05 ± 0.07	ns
PSGL‐1	0.24 ± 0.16	0.72 ± 0.33	.014	1.12 ± 0.43	1.20 ± 0.13	ns	1.11 ± 0.17	1.00 ± 0.00	ns

	Ductules		p	Parenchyma		p
	MUL	Control		MUL	Control
CK7	1.17 ± 0.26	1.03 ± 0.05	ns	1.08 ± 0.65	0.11 ± 0.12	<.001

Note: Scoring range 0–3, over 20 visual fields per sample analysed. Values are in mean ± SD.

Abbreviations: CK7, cytokeratin 7; PSGL‐1, p‐selectin glycoprotein ligand‐1; SMA, alpha smooth muscle actin;