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. 2022 Apr 8;117(8):2264–2272. doi: 10.1111/add.15881

TABLE 2.

Hazard ratios (HR) for the risk of bipolar disorder in northern Finland birth cohort 1986 in different groups of cannabis use

Frequency of cannabis use Sample size No cannabis use Once or more
Cases Cases HR 95% CI
Bipolar disorder Crude 6325 55 11 3.46 1.81–6.61
Model 1 5413 49 9 3.00 1.47–6.13
Model 2 5190 49 9 2.34 1.11–4.94
Model 3 4992 47 9 1.70 0.73–3.98

Model 1: sex, family structure, parental psychiatric disorder; model 2: sex, family structure, parental psychiatric disorder, YSR total; model 3: sex, family structure, parental psychiatric disorder, YSR total, frequent alcohol intoxications past year, daily smoking, other illicit substance use. Statistically significant results in bold type. CI = confidence interval; YSR = Youth Self Report.