TABLE 3.
Summary of pharmacodynamic parameter estimates
| Parameter | Population estimate | Standard error |
|---|---|---|
| Slope | 0.0140 | 0.0006 |
| Effect of baseline CD20 on slope a | 0.272 | 0.051 |
| Lifespan (d) | 391 | 50.2 |
| Baseline CD20 (cells μL−1) | 135 | 6.08 |
| kCD19 (d−1) | 0.0751 | 0.0103 |
| Interindividual variability b | ||
| ηSlope | 51.8 | 3.3 |
| ηLifespan | 126 | 10 |
| ηBaseline CD20 | 59.2 | 3.9 |
| ηkCD19 | 110 | 17 |
| Residual variability | ||
| Proportional error b | 60.8 | 1.6 |
kCD19, rate constant representing the maturation of pro‐B to CD20+ B cells in the circulation; η, interindividual variability.
a
Natural exponents.
b
Displayed as %CV.