FIGURE 1.

Multiple mediator models to determine the contribution of the different fat depots (SAT, VAT, and IHL) on the difference (or change) in C3. (A) Multiple mediator model in which ΔVAT, but not ΔSAT or ΔIHL, was an independent mediator of the association between the weight‐loss intervention and ΔC3 (n = 49). (B) Multiple mediator model adjusted for age in which VAT and ln‐transformed IHL, but not SAT, were significant mediators of the cross‐sectional association between BMI and plasma C3 (n = 76). IHL, intrahepatic lipid; SAT, subcutaneous adipose tissue; VAT, visceral adipose tissue [Color figure can be viewed at wileyonlinelibrary.com]