TABLE 2.

Plasma complement concentration before and after the 8‐week dietary intervention

	Weight‐stable control group a		Weight‐loss group b		Treatment effect
	Baseline	Follow‐up	Baseline	Follow‐up	Mean change (95% CI)	p value
Factor D (mg/L)	0.96 ± 0.20	0.97 ± 0.19	0.99 ± 0.22	0.96 ± 0.20	−0.03 (−0.09 to 0.02)	0.237
C3 (g/L)	1.62 ± 0.22	1.58 ± 0.22	1.53 ± 0.25	1.37 ± 0.18	−0.15 (−0.23 to −0.07)	<0.001
C3a (μg/L)	35.3 (32.3 to 46.7)	35.0 (29.5 to 42.3)	35.5 (26.9 to 49.4)	40.0 (26.4 to 60.7)	3.74 (−2.50 to 9.98)	0.234

Note: Bold font represents statistically significant data. P value of treatment effect was obtained by one‐factor ANCOVA with baseline value as covariate. C3a concentrations at baseline and follow‐up were skewed distributed, whereas the change of C3a concentration showed a normal distribution. When C3a was ln‐transformed in a sensitivity analysis, the effect of the weight‐loss intervention was comparable.

^a n = 26.

^b n = 23.