FIGURE 4.

Regulation of keratinocyte‐induced chemotaxis of immune cells by upstream inflammatory and EGFR signalling. Regulators predicted to be upstream of keratinocyte‐enriched lesional skin differently expressed genes (KELS DEGs) were identified using ingenuity pathway analysis (IPA). The KELS DEGs responsible for chemotaxis and known to be downstream of these regulators were then analysed using IPA, with the predicted promotion or chemotaxis of individual immune cell types given by the activity z‐score. Cell types and upstream regulators were clustered using Euclidean distance and complete linkage. Cluster 1: Post‐dupilumab treated lesional versus non‐lesional skin, KELS; Cluster 2: Post‐dupilumab treatment versus pre‐treatment lesional skin. White coloration represents zero significant change