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. 2022 Jul 20;100(8):653–666. doi: 10.1111/imcb.12571

Figure 1.

Figure 1

Antibodies generated following exposure to streptococcal recombinant proteins react with different host proteins. Indirect ELISAs were performed in duplicates to determine host protein cross‐reactivity of rat sera from GAS rM5 (closed squares), SDSE Stg480 antigen–injected rats (closed triangles) and PBS controls (closed circles). Significantly (P < 0.01) higher titers of (a) serum IgG reactivity were observed in rats injected with GAS rM5 and SDSE Stg480 with corresponding antigens and cross‐reactivity against host proteins including (b) cardiac myosin, (c) tropomyosin, (d) laminin, collagens (e) I and (f) IV, (g) DR1 and (h) DR2, (i) tubulin and (j) lysogangliosideGM1 than in control rats injected with PBS. Data are from one of two experiments with age‐matched rats injected with GAS rM5 (n = 5) and SDSE Stg480 (n = 6). Error bars represent standard errors of the mean. **P < 0.01, ***P < 0.001, by one‐way ANOVA with Tukey’s post hoc multiple comparison test. DR, dopamine receptor; GAS, group A streptococcus; Ig, immunoglobulin; PBS, phosphate‐buffered saline; SDSE, Streptococcus dysgalactiae subspecies equisimilis.