Figure 6.

Representative western blot images illustrate the binding pattern of the IgG from pooled sera of rats injected with GAS rM5 (a) and SDSE Stg480 (b) with purified DR1 and DR2, tubulin and lysoganglioside_GM1 and bands on these blots were observed at ~48, ~50 and ~52 kDa. Antibodies in pooled sera from rats injected with GAS rM5 (c) and SDSE Stg480 (d) to lysates of the striatum and cerebellum from naïve rats. Bands on these blots were observed at ~55 and ~70 kDa, which is consistent with the known molecular weights of DR1, DR2, lysoganglioside_GM1 and tubulin, respectively. Moreover, these sera did not recognize proteins in kidney lysates used as non‐neuronal control. Data are from one of two experiments with age‐matched rats injected with GAS rM5 (n = 5) and SDSE Stg480 (n = 6). DR, dopamine receptor; GAS, group A streptococcus; Ig, immunoglobulin; SDSE, Streptococcus dysgalactiae subspecies equisimilis; GAPDH, Glyceraldehyde‐3‐phosphate dehydrogenase.