TABLE 1.
Overview of individual predictors of major bleeding identified in VTE studies
| Variable | Relevant studies | Strength of association (univariate) | |||
|---|---|---|---|---|---|
| No association | Limited (OR 1–2) | Moderate (OR 2–5) | Strong (OR >5) | ||
| Prior bleeding | 15, 18, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42 | IIIII | IIIIIIIIII | ||
| Renal insufficiency | 15, 18, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 43 | I | IIIIIII | IIIII | II |
| Cancer | 15, 18, 19, 31, 32, 33, 34, 35, 39, 40, 41, 43 | IIII | II | IIIIII | |
| Anemia | 15, 32, 33, 35, 36, 37, 38, 40, 41, 43 | II | III | IIIIII | |
| Elderly | 15, 18, 19, 30, 32, 33, 35, 36, 37, 39, 40, 41 | II | IIIIII | IIII | |
| Use of platelet inhibitors or non‐steroidal anti‐inflammatory drugs | 15, 18, 30, 31, 32, 33, 34, 37, 38, 40 | III | IIIII | II | |
| Hypertension | 15, 30, 31, 34, 37, 38, 40, 41 | III | IIII | I | |
| Frequent falls | 32, 34, 37 | III | |||
| Liver disease | 31, 33, 36, 37, 41 | II | III | ||
| Sex | 18, 19, 31, 33, 36, 37, 38, 39, 40, 41 | IIIII | IIII | ||
| Prior stroke | 31, 32, 33, 34, 36, 37, 38, 40, 41 | IIIII | III | ||
| Thrombocytopenia | 32, 37, 41 | I | I | I | |
| Labile INR | 30, 32, 34 | II | I | ||
| Diabetes | 32, 33, 34, 37, 38, 40, 41 | IIIII | II | ||
Note: Predictors are ranked on strength of association. Modifiable (green), potentially modifiable (gray), and non‐modifiable (white) predictors are color coded.
Abbreviations: INR, international normalized ratio; OR, odds ratio; VTE, venous thromboembolism.