TABLE 1.
The eight newly identified genetic loci associated with anorexia nervosa
| CHR | Lead SNP | Nearest gene | Functions | pValue |
|---|---|---|---|---|
| 3 | rs9821797 | NCKIPSD | Growth and cellular signaling in dendrites and sarcomeres; stress fiber formation (Cho et al., 2013). | 6.99 × 10−15 |
| 11 | rs6589488 | CADM1 | Cellular adhesion; neural network formation; synaptic formation and number (Jin et al., 2019). | 6.31 × 10−11 |
| 2 | rs2287348 | ASB3and ERLEC1 |
ASB3: Phosphorylation and ubiquitination (Chung et al., 2005). ERLEC1: N‐glycan binding (Cruciat et al., 2006). |
5.62 × 10−9 |
| 10 | rs2008387 | MGMT | Alkylating agent removal (Yu et al., 2020). | 1.73 × 10−8 |
| 3 | rs9874207 | FOXP1 | Transcription factor (Siper et al., 2017). | 2.05 × 10−8 |
| 1 | rs10747478 | PTBP2 | RNA splicing in neuronal cell maturation (Romanelli et al., 2013). | 3.13 × 10−8 |
| 5 | rs370838138 | CDH10 | Sodium dependent intercellular adhesion (Kools et al., 1999). | 3.17 × 10−8 |
| 3 | rs13100344 | NSUN3 | Catlysation of 5‐formylcytadine at position 34 of methionine transfer RNA (Nakano et al., 2016) | 4.12 × 10−8 |
Note: Eight genetic loci were identified in the 2019 ANGI GWA by gene proximity to each lead SNP. Lead SNP was determined as the most strongly associated. p‐Value was considered significant (after Bonferroni adjustment) at ≤.05. The major functions for each of the nearest genes to the lead SNP have been described in column 4.
Abbreviations: ASB3, ankyrin repeat and SOCS box containing 3; CADM1, cell adhesion molecule 1; CDH10, cadherin 10; CHR, chromosome; ERLEC1, endoplasmic reticulum lectin 1; FOXP1, forkhead box P1; MGMT, O‐6‐methylguanine‐DNA methyltransferase; NCKIPSD, NCK interacting protein with SH3 domain; NSUN3, NOP2/Sun RNA methyltransferase 3; PTBP2, polypyrimidine tract binding protein 2; RNA, ribonucleic acid; rs, reference SNP accession number; SNP, single nucleotide polymorphism.
Source: Adapted from “Genome‐wide association study identifies eight risk loci and implicates metabo‐psychiatric origins for anorexia nervosa” by Watson et al., 2019, Nature Genetics, 5(8), pp. 1207–1214 (doi: 10.1038/s41588‐019‐0439‐2).