TABLE 4.

Spontaneous bleeds during the study (safety population)

Spontaneous bleeds	Cohort 1 (100 mg) (n = 8)	Cohort 2 (225 mg) (n = 8)	Cohort 3 (400 mg) (n = 8)	Total (N = 24)
Participants with spontaneous bleeds, n (%)	7 (87.5)	7 (87.5) a	3 (37.5)	17 (70.8)
Number of spontaneous bleeds, n (%)	79	37	12	128
Mild	69 (87.3)	16 (43.2)	7 (58.3)	92 (71.9)
Moderate	10 (12.7)	20 (54.1)	5 (41.7)	35 (38.0)
Severe	0	1 (2.7)	0	1 (2.9)
Treated	65 (82.3)	25 (67.6)	11 (91.7)	101 (78.9)
Untreated	14 (17.7)	12 (32.4)	1 (8.3)	27 (21.1)

Data are shown for each participant based on their initial dose cohort.

^a Number of bleeds recorded for n = 7 participants in Cohort 2.