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Model for the interplay between macrophages and hepatocytes in the context of APAP hepatotoxicity. Proposed model for the cross talk between macrophages and hepatocytes modulated by APAP and involving IL1β-mediated NFκB signaling and SIRT1 degradation in hepatocytes. To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars
