Figure 7.

Amplification of interleukin (IL)‐17A signalling pathway by miR‐378a in keratinocytes. Our findings suggest a model in which miR‐378a is induced by IL‐17A via nuclear factor kappa B (NF‐κB), C/EBP‐β and IκBζ in keratinocytes. Induction of miR‐378a leads to the suppression of NFKBIA/IκBα, which allows for activation of the NF‐κB pathway including the nuclear translocation of p65, leading to further induction of inflammatory mediators such as IL‐8/CXCL8 and CCL20. The baseline intracellular level of miR‐378a may regulate the magnitude of the response to triggers activating the NF‐κB‐pathway. [Colour figure can be viewed at wileyonlinelibrary.com]