Figure 5.
Immune deconvolution analysis from a bulk RNA sequence data showed: (A) depletion of relative abundance of (1) cytotoxic CD8+ T cells; and (2) antigen‐presenting dendritic cells; and (3) increased infiltration of immune regulatory CD4+ memory activated T cells in tumours compared to nonmalignant leukoplakia lesions that provided evidence for immune suppression in oral tumour progression. (B) The higher abundance of inflammatory mast cells and M0 macrophages in tumours indicates increased inflammation in tumours promoting tumorigenesis.