Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic representation of lncRNA AK018453 contributing to the pathology of EAE mice via regulating TRAP1/Smad pathway. Response to IL‐17 stimulation, AK018453 is upregulated in astrocytes, which regulates epigenetically the expression of TRAP1 through interacting with CBP/P300, in turn promotes the production of pro‐inflammatory cytokines such as TNF‐α, CXCL10, and MCP‐1, thus aggravating the EAE progression
