Table 2.

Results of mendelian randomization analysis

			EAS					EUR
Trait	Method	No. of SNPs	beta	SE	P‐value	q‐value	No. of SNPs	beta	SE	P‐value	q‐value
BMI	Inverse variance weighted	62	−0.211	0.113	0.0617	0.434	298	−0.165	0.0654	0.0116	0.0514
	Weighted median	62	−0.135	0.115	0.241	0.530	298	−0.125	0.0727	0.0860	0.229
	MR Egger	62	0.178	0.364	0.625	0.772	298	0.280	0.191	0.142	0.341
	MR‐PRESSO	60	−0.125	0.0949	0.192	0.530	278	−0.140	0.0561	0.0134	0.0514
	Egger intercept				0.264					0.0135
CRP	Inverse variance weighted	6	−0.0530	0.141	0.706	0.795	183	−0.0923	0.0378	0.0146	0.0514
	Weighted median	6	−0.0920	0.143	0.520	0.772	183	−0.109	0.0422	0.0100	0.0514
	MR Egger	6	0.197	0.342	0.596	0.772	183	−0.0602	0.0530	0.258	0.442
	MR‐PRESSO	6	NA	NA	NA		176	−0.101	0.0332	2.79E−03	0.0514
	Egger intercept				0.465					0.389
HDL‐C	Inverse variance weighted	50	0.0756	0.0364	0.0379	0.431	247	0.0412	0.0387	0.287	0.459
	Weighted median	50	0.0567	0.0543	0.296	0.530	247	−0.0184	0.0439	0.674	0.887
	MR Egger	50	−6.90E−03	0.0656	0.917	0.917	247	−0.0786	0.0559	0.161	0.351
	MR‐PRESSO	50	NA	NA	NA		235	0.0406	0.0323	0.209	0.386
	Egger intercept				0.139				2.00E−03	3.68E−03
BS	Inverse variance weighted	15	−0.117	0.105	0.265	0.530	93	−0.135	0.0726	0.0629	0.189
	Weighted median	15	−0.145	0.141	0.303	0.530	93	−0.0485	0.0694	0.485	0.728
	MR Egger	15	−0.124	0.529	0.818	0.859	93	−0.0421	0.118	0.723	0.887
	MR‐PRESSO	15	NA	NA	NA		86	−0.126	0.0503	0.0144	0.0514
	Egger intercept				0.989					0.321
TGs	Inverse variance weighted	36	−0.0469	0.0625	0.452	0.730	204	−0.0143	0.0428	0.739	0.887
	Weighted median	36	−0.0960	0.0671	0.152	0.530	204	−0.0208	0.0444	0.640	0.887
	MR Egger	36	−0.207	0.0975	0.0409	0.431	204	0.0825	0.0616	0.182	0.364
	MR‐PRESSO	34	−0.0626	0.0564	0.275	0.530	192	6.83E−03	0.0340	0.841	0.910
	Egger intercept				0.0452					0.0316
SBP	Inverse variance weighted	22	0.207	0.164	0.206	0.530	158	−0.0134	0.0831	0.872	0.910
	Weighted median	22	0.0794	0.161	0.623	0.772	158	0.0212	0.0846	0.802	0.910
	MR Egger	22	0.987	0.574	0.101	0.530	158	0.702	0.268	9.56E−03	0.0514
	MR‐PRESSO	21	0.0416	0.114	0.719	0.795	153	−5.01E−03	0.0687	0.942	0.942
	Egger intercept				0.172					5.65E−03

Bold numbers represent results for prioritized analysis based on the significance of Egger intercept (if P > 0.05, we prioritized the “inverse variance–weighted” method, whereas if P < 0.05, we prioritized other methods).

^†Mendelian randomization (MR) pleiotropy residual sum and outlier (MR‐PRESSO) beta effects were calculated after removing the outliers, which were pleiotropic variants. If there was no outlier, we described “NA” in the column. The number of single nucleotide polymorphism (SNPs) in MR‐PRESSO was that after removing the outliers.

BMI, body mass index; BS, blood sugar; CRP, C‐reactive protein; EAS, East Asian; EUR, European; HDL‐C, high‐density lipoprotein cholesterol; SBP, systolic blood pressure; SE, standard error; TGs, triglycerides.