Table 3.
Infections among the general population and patients with any psoriasis
| Patient‐years at risk | Number of events | HR (95% CI) crude | P‐values | HR (95% CI) adjusteda | P‐values | |
|---|---|---|---|---|---|---|
| Any infections (rare or severe) | ||||||
| Reference | 4 987 540 | 118 756 | – | – | – | – |
| Psoriasis | 801 860 | 24 897 | 1·31 (1·29–1·33) | < 0·0001 | 1·29 (1·27–1·31) | < 0·0001 |
| Severe infections | ||||||
| Any severe infections | ||||||
| Reference | 4 993 240 | 118 059 | – | – | – | – |
| Psoriasis | 803 150 | 24 742 | 1·31 (1·29–1·32) | < 0·0001 | 1·29 (1·27–1·31) | < 0·0001 |
| CNS infections | ||||||
| Reference | 5 545 840 | 1181 | – | – | – | – |
| Psoriasis | 924 040 | 274 | 1·39 (1·22–1·59) | < 0·0001 | 1·37 (1·20–1·56) | < 0·0001 |
| URTI | ||||||
| Reference | 5 518 200 | 7019 | – | – | – | – |
| Psoriasis | 917 770 | 1594 | 1·37 (1·30–1·45) | < 0·0001 | 1·36 (1·29–1·43) | < 0·0001 |
| Pulmonary infections | ||||||
| Reference | 5 404 440 | 41 751 | – | – | – | – |
| Psoriasis | 892 900 | 8788 | 1·28 (1·25–1·31) | < 0·0001 | 1·25 (1·22–1·28) | < 0·0001 |
| Heart infections | ||||||
| Reference | 5 542 010 | 1924 | – | – | – | – |
| Psoriasis | 923 450 | 416 | 1·30 (1·17–1·44) | < 0·0001 | 1·26 (1·13–1·40) | < 0·0001 |
| GI infections | ||||||
| Reference | 5 393 260 | 30 474 | – | – | – | – |
| Psoriasis | 892 640 | 6411 | 1·27 (1·24–1·31) | < 0·0001 | 1·25 (1·22–1·29) | < 0·0001 |
| UTI | ||||||
| Reference | 5 452 470 | 24 881 | – | – | – | – |
| Psoriasis | 905 170 | 5114 | 1·24 (1·20–1·28) | < 0·0001 | 1·23 (1·19–1·26) | < 0·0001 |
| Gynaecological infections | ||||||
| Reference | 2 730 940 | 1202 | – | – | – | – |
| Psoriasis | 455 790 | 246 | 1·23 (1·07–1·41) | 0·004 | 1·20 (1·04–1·37) | 0·01 |
| Musculoskeletal infections | ||||||
| Reference | 5 533 190 | 3095 | – | – | – | – |
| Psoriasis | 920 980 | 764 | 1·48 (1·37–1·61) | < 0·0001 | 1·42 (1·31–1·54) | < 0·0001 |
| Skin and subcutaneous infections | ||||||
| Reference | 5 442 850 | 18 352 | – | – | – | – |
| Psoriasis | 897 730 | 4515 | 1·49 (1·44–1·54) | < 0·0001 | 1·45 (1·41–1·50) | < 0·0001 |
| Opportunistic infections | ||||||
| Reference | 5 531 270 | 4807 | – | – | – | – |
| Psoriasis | 920 870 | 1062 | 1·33 (1·24–1·42) | < 0·0001 | 1·30 (1·21–1·38) | < 0·0001 |
| Other infections | ||||||
| Reference | 5 498 270 | 15 428 | – | – | – | – |
| Psoriasis | 912 930 | 3486 | 1·37 (1·32–1·42) | < 0·0001 | 1·34 (1·29–1·39) | < 0·0001 |
| Sepsis | ||||||
| Reference | 5 519 210 | 13 287 | – | – | – | – |
| Psoriasis | 917 420 | 3077 | 1·39 (1·34–1·45) | < 0·0001 | 1·35 (1·29–1·40) | < 0·0001 |
| Rare | ||||||
| Any rare infections | ||||||
| Reference | 5 540 140 | 1761 | – | – | – | – |
| Psoriasis | 922 800 | 396 | 1·35 (1·21–1·51) | < 0·0001 | 1·34 (1·20–1·50) | < 0·0001 |
| HIV | ||||||
| Reference | 5 549 580 | 214 | – | – | – | – |
| Psoriasis | 924 980 | 55 | 1·54 (1·14–2·07) | 0·0044 | 1·58 (1·17–2·13) | 0·0025 |
| Hepatitis | ||||||
| Reference | 5 543 860 | 1177 | – | – | – | – |
| Psoriasis | 923 550 | 276 | 1·41 (1·23–1·60) | < 0·0001 | 1·39 (1·22–1·59) | < 0·0001 |
| Tuberculosis | ||||||
| Reference | 5 549 360 | 391 | – | – | – | – |
| Psoriasis | 925 030 | 69 | 1·06 (0·82–1·37) | 0·66 | 1·05 (0·81–1·36) | 0·72 |
CI, confidence interval; CNS, central nervous system; GI, gastrointestinal; HR, hazard ratio; URTI, upper respiratory tract infections; UTI, urinary tract infections. aAdjusted for sex, age, ethnicity, socioeconomic status, alcohol‐related conditions and Charlson Comorbidity Index.