Table 5.
Infections among the general population and patients with severe psoriasis
| IR per 100 000 person‐years among the general population (95% CI) | IR per 100 000 person‐years among patients with severe psoriasis (95% CI) | IR differences per 100 000 person‐years (95% CI) | |
|---|---|---|---|
| Any infections (rare or severe) | 2351·9 (2322·9–2381·2) | 3847·7 (3754·3–3943·4) | 1495·8 (1431·4–1562·2) |
| Severe infections | |||
| Any severe infections | 2335·0 (2306·1–2364·1) | 3824·6 (3731·6–3919·9) | 1489·6 (1425·5–1555·8) |
| CNS infections | 22·03 (19·53–24·84) | 40·32 (32·47–50·06) | 18·29 (12·94–25·22) |
| URTI | 137·40 (130·92–144·21) | 226·99 (207·11–248·79) | 89·59 (76·19–104·6) |
| Pulmonary infections | 732·82 (717·46–748·50) | 1248·2 (1199·32–1299·0) | 515·3 (481·9–550·5) |
| Heart infections | 34·44 (31·28–37·92) | 59·56 (49·84–71·18) | 25·12 (18·56–33·26) |
| GI infections | 581·99 (568·30–569·01) | 872·69 (832·10–915·25) | 290·7 (263·8–346·24) |
| UTI | 445·53 (433·65–457·73) | 663·59 (628·63–700·48) | 218·1 (194·9–242·8) |
| Gynaecological infections | 40·33 (35·52–45·79) | 54·174 (41·49–70·73) | 13·84 (5·98–24·94) |
| Musculoskeletal infections | 55·23 (51·19–59·60) | 110·88 (97·27–126·39) | 55·64 (46·08–66·78) |
| Skin and subcutaneous tissue infections | 342·69 (332·28–353·44) | 671·88 (636·41–709·32) | 329·19 (304·13–355·88) |
| Opportunistic infections | 88·37 (83·20–93·85) | 181·09 (163·46–200·63) | 92·72 (80·25–106·8) |
| Other infections | 298·21 (288·56–308·18) | 542·26 (510·90–575·56) | 244·1 (222·3–267·4) |
| Sepsis | 235·25 (226·72–244·1) | 450·33 (421·94–480·63) | 215·1 (195·2–236·5) |
| Rare | |||
| Any rare infections | 31·45 (28·44–34·79) | 55·69 (46·31–66·97) | 24·24 (17·87–32·18) |
| HIV | 4·15 (3·15–5·48) | 7·86 (4·81–12·82) | 3·70 (1·67–7·34) |
| Hepatitis | 20·04 (17·66–22·73) | 32·48 (25·52–41·34) | 12·44 (7·86–18·61) |
| Tuberculosis | 7·56 (6·15–9·28) | 15·72 (11·11–22·22) | 8·16 (4·96–12·94) |
CI, confidence interval; CNS, central nervous system; GI, gastrointestinal; IR, incidence rate; URTI, upper respiratory tract infections; UTI, urinary tract infections.