Table 3.
Overview of individual dermoscopy features present in tiny and nontiny melanomas. a
| Method and features | Tiny (n = 85) | Nontiny (n = 214) | P |
|---|---|---|---|
| Menzies method, n (%) | |||
| Asymmetry of pattern | 64 (75.3) | 189 (88.3) | < 0.01 |
| Number of colours, median (IQR) | 2 (2–3) | 3 (2–3) | < 0.001 |
| ≥ 5 colours | 0 (0.0) | 10 (4.7) | 0.04 |
| Blue–whitish veil | 1 (1.2) | 8 (3.7) | 0.24 |
| Brown dots | 56 (65.9) | 151 (70.6) | 0.43 |
| Pseudopods | 3 (3.4) | 0 (0.0) | 0.02 b |
| Radial streaming | 11 (12.9) | 2 (0.9) | < 0.001 |
| Scar‐like depigmentation | 5 (5.9) | 23 (10.7) | 0.19 |
| Peripheral black dots and globules | 15 (17.6) | 25 (11.7) | 0.17 |
| Multiple blue–grey dots (peppering) | 2 (2.4) | 39 (18.2) | < 0.001 |
| Broadened network | 27 (31.8) | 80 (37.4) | 0.36 |
| Correctly classified as MM | 56 (65.9) | 175 (81.8) | 0.003 |
| 7‐point checklist, n (%) | |||
| Atypical pigment network | 38 (44.7) | 129 (60.3) | 0.01 |
| Blue–whitish veil | 1 (1.2) | 8 (3.7) | 0.24 |
| Atypical vascular pattern | 8 (9.4) | 41 (19.2) | 0.04 |
| Irregular dots and globules | 65 (76.5) | 159 (74.3) | 0.70 |
| Irregular streaks | 12 (14.1) | 3 (1.4) | < 0.001 |
| Regression structures | 18 (21.2) | 81 (37.9) | < 0.01 |
| Irregular pigmentation | 31 (36.5) | 62 (29.0) | 0.21 |
| Correctly classified as MM | 44 (51.8) | 140 (65.4) | 0.04 |
| 3‐point checklist, n (%) | |||
| Asymmetry in structure or colour | 66 (77.6) | 196 (91.6) | 0.001 |
| Atypical network | 40 (47.1) | 129 (60.3) | 0.03 |
| Blue–white structures | 21 (24.7) | 83 (38.8) | 0.02 |
| Correctly classified as MM | 43 (50.6) | 144 (67.3) | 0.01 |
| Revised pattern analysis (chaos and clues), n (%) | |||
| Asymmetry of pattern | 63 (74.1) | 189 (88.3) | < 0.01 |
| Asymmetry of colour | 44 (51.8) | 172 (80.4) | < 0.001 |
| Grey or blue structures | 22 (25.9) | 81 (37.9) | 0.05 |
| Thick lines | 28 (32.9) | 72 (33.6) | 0.91 |
| White lines | 4 (4.7) | 22 (10.3) | 0.12 |
| Eccentric structureless areas | 17 (20.0) | 59 (27.6) | 0.18 |
| Peripheral black dots or clods | 15 (17.6) | 25 (11.7) | 0.17 |
| Radial lines or pseudopods | 12 (14.1) | 2 (0.9) | < 0.001 |
| Polymorphous vessels | 5 (5.9) | 24 (11.2) | 0.16 |
| Polygons | 1 (1.2) | 20 (9.3) | 0.01 |
| Correctly classified as MM | 54 (63.5) | 160 (74.8) | 0.07 |
| Atypical vessels, n (%) | |||
| Dotted | 6 (7.1) | 36 (16.9) | 0.03 |
| Linear | 6 (7.1) | 17 (7.9) | 0.80 |
| Coiled or glomerular | 2 (2.4) | 11 (5.1) | 0.29 |
| Looped | 0 (0.0) | 4 (1.9) | 0.58 b |
| Serpentine | 2 (2.4) | 5 (2.3) | 0.99 b |
| Comma‐like | 0 (0.0) | 3 (1.4) | 0.56 b |
| Corkscrew | 1 (1.2) | 4 (1.9) | 0.99 |
| Global pattern, n (%) | |||
| Homogeneous | 5 (6.0) | 3 (1.4) | 0.03 |
| Multicomponent | 8 (9.4) | 53 (24.8) | 0.003 |
| Starburst | 12 (14.1) | 0 (0.0) | < 0.001 |
| Reticular | 13 (15.3) | 52 (24.3) | 0.09 |
| Globular | 9 (10.6) | 2 (0.9) | < 0.001 |
| Unspecific | 38 (44.7) | 104 (48.6) | 0.54 |
| Additional features, n (%) | |||
| Chrysalis | 4 (4.7) | 22 (10.3) | 0.12 |
| Shiny white blotches | 2 (2.4) | 7 (3.3) | 0.68 |
| Rosettes | 1 (1.2) | 3 (1.4) | 0.99 b |
| Negative network | 3 (3.5) | 7 (3.3) | 0.91 |
| Milky‐red areas | 4 (4.7) | 20 (9.3) | 0.19 |
| Milky‐red globules | 1 (1.2) | 3 (1.4) | 0.99 b |
MM, malignant melanoma.
a
13 lesions were excluded for the dermoscopy analysis due to low‐quality images: these comprised 1 patient with a tiny MM and 12 patients with nontiny MMs.
b
P values were calculated with Fisher exact test as > 50% of cells had an expected count of < 5 individuals; all other P values were calculated with χ2 test.