Table 4.
Prevalence of dermoscopy criteria for patients with invasive vs. in situ tiny melanomas and univariable logistic regression for dermoscopy features predicting invasiveness in patients with tiny melanomas. a
| Invasive (n = 38) | In situ (n = 47) | OR | 95% CI | P of 95% CI | |
|---|---|---|---|---|---|
| Menzies' method, n (%) | |||||
| Asymmetry of pattern | 28 (73.7) | 36 (76.6) | 0.86 | 0.32–2.30 | 0.76 |
| ≥ 5 colours | 0 (0.0) | 0 (0.0) | NA | NA | NA |
| Blue–whitish veil | 0 (0.0) | 1 (2.1) | 0.40 b | 0.02–10.17 | 0.57 |
| Brown dots | 23 (60.5) | 33 (70.2) | 0.65 | 0.26–1.60 | 0.35 |
| Pseudopods | 2 (5.3) | 1 (2.1) | 2.56 | 0.22–29.31 | 0.45 |
| Radial streaming | 6 (15.8) | 5 (10.6) | 1.58 | 0.44–5.42 | 0.48 |
| Scar‐like depigmentation | 2 (5.3) | 3 (6.4) | 0.82 | 0.13–5.14 | 0.83 |
| Peripheral black dots and globules | 5 (13.2) | 10 (21.3) | 0.56 | 0.17–1.81 | 0.33 |
| Multiple blue–grey dots (peppering) | 0 (0.0) | 2 (4.3) | 0.26 b | 0.02–5.51 | 0.51 |
| Broadened network | 11 (28.9) | 16 (34.0) | 0.79 | 0.31–1.99 | 0.62 |
| 7‐point checklist, n (%) | |||||
| Atypical pigment network | 16 (42.1) | 22 (46.8) | 0.83 | 0.35–1.96 | 0.67 |
| Blue–whitish veil | 0 (0.0) | 1 (2.1) | 0.43 b | 0.02–11.03 | 0.61 |
| Atypical vascular pattern | 8 (21.1) | 0 (0.0) | 26.48 b | 1.47–475.50 | < 0.01 |
| Irregular dots and globules | 26 (68.4) | 39 (83.0) | 0.44 | 0.16–1.24 | 0.12 |
| Irregular streaks | 6 (15.9) | 6 (12.8) | 1.28 | 0.38–4.35 | 0.69 |
| Regression structures | 11 (28.9) | 7 (14.9) | 2.32 | 0.80–6.76 | 0.12 |
| Irregular pigmentation | 17 (44.7) | 14 (29.8) | 1.91 | 0.78–4.67 | 0.16 |
| 3‐point checklist, n (%) | |||||
| Asymmetry in structure or colour | 30 (78.9) | 36 (76.6) | 1.15 | 0.41–3.22 | 0.80 |
| Atypical network | 17 (44.7) | 23 (48.9) | 0.85 | 0.36–1.99 | 0.70 |
| Blue–white structures | 12 (31.6) | 9 (19.1) | 1.95 | 0.72–5.29 | 0.19 |
| Revised pattern analysis (chaos and clues), n (%) | |||||
| Asymmetry of pattern | 28 (73.7) | 36 (76.6) | 0.75 | 0.28–1.99 | 0.56 |
| Asymmetry of colour | 20 (52.6) | 24 (51.1) | 1.07 | 0.45–2.51 | 0.89 |
| Grey or blue structures | 15 (39.5) | 7 (14.9) | 3.73 | 1.33–10.47 | 0.01 |
| Thick lines | 10 (26.3) | 18 (38.3) | 0.58 | 0.23–1.46 | 0.25 |
| White lines | 4 (10.5) | 0 (0.0) | 12.39 b | 0.65–237.80 | 0.04 |
| Eccentric structureless areas | 5 (13.2) | 12 (25.5) | 0.44 | 0.14–1.39 | 0.16 |
| Peripheral black dots or clods | 5 (13.2) | 10 (21.3) | 0.56 | 0.17–1.81 | 0.33 |
| Radial lines or pseudopods | 6 (15.8) | 6 (12.8) | 1.28 | 0.38–4.35 | 0.69 |
| Polymorphous vessels | 5 (13.2) | 0 (0.0) | 15.60 b | 0.83–291.70 | 0.02 |
| Polygons | 0 (0.0) | 1 (2.1) | 0.40 b | 0.02–10.17 | 0.57 |
| Atypical vessels, n (%) | |||||
| Dotted | 6 (15.9) | 0 (0.0) | 19.00 b | 1.03–349.10 | < 0.01 |
| Linear | 6 (15.9) | 0 (0.0) | 19.00 b | 1.03–349.10 | < 0.01 |
| Coiled or glomerular | 2 (5.3) | 0 (0.0) | 6.51 b | 0.31–139.71 | 0.18 |
| Serpentine | 2 (5.3) | 0 (0.0) | 6.51 b | 0.31–139.71 | 0.18 |
| Corkscrew | 1 (2.6) | 0 (0.0) | 3.8 b | 0.15–95.98 | 0.39 |
| Global pattern, n (%) | |||||
| Homogeneous | 2 (5.3) | 3 (6.5) | 0.80 | 0.13–5.03 | 0.81 |
| Multicomponent | 4 (10.5) | 4 (8.5) | 1.27 | 0.30–5.43 | 0.75 |
| Starburst | 6 (15.9) | 6 (12.8) | 1.28 | 0.38–4.35 | 0.69 |
| Reticular | 3 (7.9) | 10 (21.3) | 0.32 | 0.08–1.25 | 0.10 |
| Globular | 3 (7.9) | 6 (12.8) | 0.59 | 0.14–2.52 | 0.47 |
| Unspecific | 20 (52.6) | 18 (38.3) | 1.79 | 0.75–4.26 | 0.19 |
| Additional features, n (%) | |||||
| Chrysalis | 4 (10.5) | 0 (0.0) | 12.39 b | 0.65–237.80 | 0.04 |
| Shiny white blotches | 2 (5.3) | 0 (0.0) | 6.51 b | 0.31–139.71 | 0.18 |
| Rosettes | 1 (2.6) | 0 (0.0) | 3.8 b | 0.15–95.98 | 0.39 |
| Negative network | 2 (5.3) | 1 (2.1) | 2.56 | 0.22–29.31 | 0.45 |
| Milky‐red areas | 3 (7.9) | 1 (2.1) | 3.94 | 0.39–39.54 | 0.24 |
| Milky‐red globules | 0 (0.0) | 1 (2.1) | 0.40 b | 0.02–10.17 | 0.57 |
NA, not applicable.
a
One patient with a tiny melanoma was excluded from the analysis due to low quality image.
b
Haldane–Anscombe correction was used for cases with zero values.