FIGURE 3.

Number of patients with PNH experiencing BTH^a (A) and the number of BTH events reported (B) per 6‐month interval of the extension period in study 301^b and study 302. Abbreviations: BTH, breakthrough hemolysis; PNH, paroxysmal nocturnal hemoglobinuria. ^aIn study 301, 15 patients experienced BTH events during the extension period up to 2 years. Of these patients, 5/15 experienced BTH events across multiple periods of extension. ^bIn study 301, at 0–6 months of extension, one patient experienced two BTH events; at >6–12 months of extension, three patients experienced two BTH events; at >12–18 months of extension, one patient experienced two BTH events