TABLE 4.
Adjusted associations between eczema subclasses and early life allergic sensitization and at 12 years with eczema subclasses as the outcomes
| Eczema subclasses a | Early‐onset persistent [EOP] (59/619) | Early‐onset resolving [EOR] (51/619) | Mid‐onset persistent [MOP] (74/619) | Mid‐onset resolving [MOR] (16/619) |
|---|---|---|---|---|
| Allergic sensitization | aMOR (95% CI) b | aMOR (95% CI) b | aMOR (95% CI) b | aMOR (95% CI) b |
| Sensitization at 6 months | ||||
| Allergic sensitization [n:554] | 3.88 (2.10–7.15) * | 1.14 (0.57–2.25) | 1.41 (0.84–2.40) | 1.48 (0.49–4.53) |
| Aero sensitization [n:553] | 3.95 (1.87–8.36) | 1.31 (0.49–3.51) | 1.91 (0.93–3.91) | 3.03 (0.89–10.28) |
| Food sensitization [n:554] | 4.55 (2.45–8.47) | 1.27 (0.63–2.59) | 1.44 (0.81–2.54) | 1.70 (0.55–5.24) |
| Sensitization at 1 year | ||||
| Allergic sensitization [n:543] | 6.34 (3.34–12.07) | 2.09 (1.11–3.95) | 1.41 (0.84–2.37) | 5.06 (1.74–14.70) |
| Aero sensitization [n:543] | 4.18 (2.17–8.06) | 1.71 (0.82–3.60) | 1.59 (0.86–2.91) | 1.71 (0.45–6.40) |
| Food sensitization [n:543] | 9.53 (4.91–18.50) | 2.19 (1.12–4.30) | 1.41 (0.79–2.50) | 5.88 (2.21–15.67) |
| Sensitization at 2 years | ||||
| Allergic sensitization [n:449] | 3.94 (1.93–8.02) | 2.37 (1.26–4.43) | 2.03 (1.18–3.50) | 1.49 (0.51–4.34) |
| Aero sensitization [n:449] | 3.73 (1.89–7.37) | 2.32 (1.22–4.39) | 2.05 (1.17–3.59) | 0.77 (0.19–3.08) |
| Food sensitization [n:449] | 5.95 (2.81–12.59) | 1.62 (0.75–3.53) | 2.06 (1.10–3.87) | 2.15 (0.68–6.75) |
| Sensitization at 12 years | ||||
| Allergic sensitization [n:344] | 4.58 (1.52–13.85) | 1.50 (0.69–3.28) | 1.90 (1.02–3.53) | 1.87 (0.40–8.77) c |
| Aero sensitization [n:344] | 4.66 (1.55–14.04) | 1.54 (0.71–3.37) | 1.86 (1.01–3.42) | 2.00 (0.43–9.19) c |
| Food sensitization [n:331] | 2.89 (1.11–7.54)x | 1.99 (0.69–5.75) | 3.34 (1.65–6.76) | 1.25 (0.31–5.07) c |
Abbreviations: 95% CI, 95% confidence interval; aMOR, adjusted multinomial odds ratio; n, number of observations in the regression model.
a
Reference category: Minimal eczema
b
Adjusted for sex, parental eczema history, parental allergy history, parental education, parental occupation, Filaggrin null mutation, outdoor and indoor air pollution.
c
Firth penalized logistic regression.
*
P‐values less than .05 are bolded.