TABLE 1.
Clinical and laboratory parameters of autoimmune hemolytic anemia (AIHA) patients divided according to the development of thrombotic complications
| Thrombosis (N = 33) | No thrombosis (N = 254) | |
|---|---|---|
| Median follow‐up, days (range) | 1584 (71–8915) | 950 (28–16 483) |
| Males, N (%)/females, N (%) | 13 (39)/20 (61) | 98 (38)/156 (62) |
| Median age, years (range) | 65 (24–84) | 63 (5–96) |
| Type of AIHA, N (%) | ||
| Warm IgG+ | 9 (27.3) | 102 (40) |
| Warm IgG + C | 6 (18.3) | 24 (9.5) |
| Cold agglutinin disease | 11 (33.3) | 92 (36) |
| Mixed AIHA | 3 (9.1) | 17 (7) |
| Atypical AIHA | 4 (12) | 19 (7.5) |
| Hematologic parameters at diagnosis | ||
| Median Hb, g/dL (range) | 6.5 (2–9.9) | 7.3 (2.1–14.1) * |
| Median Ret, × 10e9/L (range) | 162 (49–570) | 165 (40–780) |
| Median LDH, × ULN (range) | 2.2 (1.18–14) | 1.5 (0–18) * |
| Median unconjugated bilirubin, mg/dL (range) | 1.38 (0.28–6) | 1.1 (0.11–6.7) |
| Median WBC, × 109/L (range) | 5.8 (3.3–14) | 7.18 (3.4–28) |
| Median PLT, × 109/L (range) | 200 (48–414) | 264 (2.66–464) |
| Median C3, mg/dL (range) | 104 (79–123) | 91 (48–116) |
| Median C4, mg/dL (range) | 17 (1–55) | 13 (6–30) |
| Hematologic parameters at thrombosis | ||
| Median Hb, g/dL (range) | 9.1 (3.2–14) | – |
| Median Ret, × 10e9/L (range) | 128 (22–400) | – |
| Median LDH, × ULN (range) | 1.49 (0–19) | – |
| Median unconjugated bilirubin, mg/dL (range) | 1.3 (0.2–4.9) | – |
| Median WBC, × 10e9/L (range) | 7.4 (1.5–25) | – |
| Median PLT, × 10e9/L (range) | 211 (77–794) | – |
Abbreviations: C3 and C4, complement fraction 3 and 4; Hb, hemoglobin; LDH, lactate dehydrogenase; PLT, platelets; Ret, reticulocytes; WBC, white blood cells.
*
p < 0.05.