Table 4.
A brief summary of clinical data for ED patients with NDD‐CNVs
| Patient | NDD‐CNVs | Diagnosis | Family history of psychiatric disorders | Developmental history | Age at Onset (years) | Severe dietary restriction | Disturbed body image | Fear of gaining weight | Binge‐eating/purging | Lifetime lowest BMI (kg/m2) | Psychiatric comorbidity | Brain MRI |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Case 1 | 45,X | AN‐R | − | Language delay | 23 | + | + | + | 12.0 | − | Cortical atrophy | |
| Case 2 | KATNAL2 deletion | AN‐BP | − | Normal | 20 | + | + | + | 12.2 | − | NA | |
| Case 3 | DIP2A deletion PTPRT deletion | AN‐BP | − | Normal | 22 | + | + | + | 11.0 | − | Cortical atrophy | |
| Case 4 | RBFOX1 deletion | AN‐BP | + | Cognitive delay | 15 | + | + | + | 10.6 | Mild ID, alcohol use disorder | Cortical atrophy | |
| Case 5 | CNTN4 deletion | AN‐R | NA | Normal | 16 | + | + | + | 14.6 | MDD | Normal | |
| Case 6 | MACROD2 deletion | ARFID | − | Low birth weight | 20 | + | 11.0 | MDD | NA | |||
| Case 7 | FAM92B deletion | AN‐R | + | Normal | 15 | + | + | + | 13.6 | − | Arachnoid cyst of middle cranial fossa |
Abbreviations: AN‐BP, anorexia nervosa binge‐eating/purging type; AN‐R, anorexia nervosa restrictive type; ARFID, avoidant/restrictive food intake disorder; ASD, autism spectrum disorder; BMI, body mass index; ID, intellectual disability; MDD, major depressive disorder; MRI, magnetic resonance imaging; NA, not available; NDD, neurodevelopmental disorder.