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. 2022 Sep 23;10:1014734. doi: 10.3389/fpubh.2022.1014734

Table 3.

Trends in age- and sex-standardized BZRA prescription rates among patients who received <3 BZRA prescriptions in 1 year between 2000 and 2019.

Group 2000 N = 7,209 2019
N = 24,962
Summary Trend 1 Trend 2
% % AAPC Years APC Years APC
Prescriptions
BZRA < 3 65.1 57.6 0.6 (−0.1; 1.3) 2000–2019 0.6 (−0.1; 1.3)
Overall 18–44 18.1 16.3 1.4 (0.6; 2.2) 2000–2012 −0.4 (−1.3; 0.6) 2012–2019 4.4 (2.6; 6.1)
Overall 45–64 24.1 21.7 0.4 (−0.1; 0.9) 2000–2012 0.9 (1.5;0.3) 2012–2019 2.6 (1.4; 3.7)
Overall 65+ 22.9 19.6 0.5 (−0.2; 1.2) 2000–2016 −0.3 (−0.7; 0.1) 2016–2019 4.7 (0.2; 9.3)
Males 23.9 21.9 0.9 (0.2; 1.6) 2000–2019 0.9 (0.2; 1.6)
Males 18–44 7.3 6.4 1.7 (0.8; 2.6) 2000–2010 −0.1 (−1.6; 1.4) 2010–2019 3.7 (2.3; 5.1)
Males 45–64 9.2 8.6 0.8 (0.2; 1.4) 2000–2012 −0.6 (−1.3; 0.1) 2012–2019 3.3 (1.9; 4.6)
Males 65+ 7.3 6.9 0.5 (0.1; 1.0) 2000–2019 0.5 (0.1; 1.0)
Females 41.2 35.7 0.4 (−0.4; 1.3) 2000–2019 0.4 (−0.4; 1.3)
Females 18–44 10.8 9.9 1.0 (0.1; 1.9) 2000–2012 −0.9 (−2.0; 0.2) 2012–2019 4.3 (2.3; 6.3)
Females 45–64 14.9 13.1 0.1 (−0.5; 0.7) 2000–2012 1.0 (1.7;0.3) 2012–2019 2.0 (0.7; 3.3)
Females 65+ 15.5 12.7 0.4 (−0.3; 1.2) 2000–2016 −0.3 (−0.8; 0.1) 2016–2019 4.8 (0.0; 9.8)

AAPC, average annual percentage change; APC, average percentage change; statistically significant trends (95% CI) in bold.