Figure 4.

Assessing the involvement of Na⁺-activated potassium channels in spike frequency adaptation and afterhyperpolarization. A, The effect of substituting extracellular LiCl for NaCl on responses evoked by prolonged depolarization for a representative example cell. n = 5 cells (5 animals). B, Responses evoked by prolonged depolarization in the presence of 1 mm quinidine. n = 4 cells (2 animals). Ca, Average instantaneous firing frequencies evoked by 200 pA depolarizing currents for 30 s in Slo2.1/2.2 double-knockout animals. n = 9 cells (5 animals). Cb, The average AHPs following the current steps in Slo2.1/2.2 double-knockout animals. Shading in C is the SE.