Fig. 3.

(A) More representative dose-response data for ReFRAME compound NSC-150117, a phosphatase inhibitor. The legend is the same as in Fig. 2, except for the hemoglobin compositions as percentage of total Hb of the donors , which are: donor 1: HbA 56.1, HbS 40.0, HbA2 3.7, HbF <1.0, MCHC 29.8 g/dL; donor 2: HbA 59.8, HbS 35.5, HbA2 3.8, HbF <1.0, MCHC 33.6 g/dL; donor 3: HbA 59.7, HbS 37.8, HbA2 3.8, HbF <1.0, MCHC 26.6 g/dL. (B) Points are measured percentage of inhibition defined by Eq. 1 for cells from 3 different donors, while the continuous curves are the fits to the data using Eq. 2 (see Materials and Methods section for equations).