Table 1.
List of antisickling compounds with LICs <10 μM
| Name of compound | IC50 (μM)* | LIC (μM)† |
|---|---|---|
| Ammonium trichlorotellurate‡,§ | 0.032 ± 0.015 | 0.031 |
| Niferidil‡,** | 10.5 | 0.031 |
| Mavatrep | 0.23 ± 0.14 | 0.123 |
| Manoalide‡ | 0.33 ± 0.09 | 0.278 |
| HR325‡ | 3.0 ± 0.86 | 0.278 |
| NSD-721‡ | 13 ± 2.0 | 0.278 |
| FT-11‡ | 1.3 ± 1.0 | 0.278 |
| Mitapivat‡ | 0.25 ± 0.16 | 0.278 |
| ARA DMAP‡ | 3.9 ± 1.1 | 1.1 |
| Pafuramidine‡ | 6.0 ± 5.8 | 1.1 |
| Cisplatin‡,§,¶ | 1.3 ± 0.2 | 1.1 |
| Cloturin‡,ǁ | 9.7 ± 0.5 | 1.1 |
| EF-4040‡ | 1.7 ± 0.4 | 1.1 |
| Cyclovalone‡ | 1.7 ± 0.7 | 1.1 |
| VML 530 | 1.5 ± 0.2 | 1.1 |
| Peruvoside‡ | NA# | 1.1 |
| ONO-7746 | 3.8 ± 2.0 | 1.1 |
| BMS-919373§,¶,ǁ | 6.4 ± 8.1 | 1.1 |
| KUX-1151‡ | 5.3 ± 5.1 | 1.1 |
| NT-113 | 3.6 ± 2.8 | 1.1 |
| Curcumin | 0.50 ± 0.14 | 1.1 |
| AEG-33783‡,§ | 1.4 ± 0.5 | 1.1 |
| VRT-532‡ | 5.8 ± 0.7 | 2.5 |
| Licochalcone A | 4.3 ± 2.4 | 2.5 |
| NSC-150117 | 2.6 ± 0.7 | 2.5 |
| AT-101§ | 2.4 ± 0.1 | 2.5 |
| Darapladib§,¶ | 2.0 ± 0.4 | 2.5 |
| Oxyfedrine hydrochloride | 2.9 ± 1.1 | 2.5 |
| Octenidine‡,§,¶ | NA# | 2.5 |
| WP-1066‡ | 3.9 ± 1.2 | 2.5 |
| Butein | 10 ± 3 | 2.5 |
| Ethacrynic acid‡ | 3.3 ± 0.9 | 2.5 |
| TS-80‡ | 3.1 ± 1.6 | 2.5 |
| SC-1 | 10 ± 5 | 2.5 |
| Tucaresol | 3.1 ± 0.3 | 2.5 |
| CBS-1114 | 7.2 ± 5.2 | 2.5 |
| YM 57158 | 2.5 ± 0.3 | 2.5 |
| Allisartan‡ | 7.8 ± 4.6 | 2.5 |
| Elisartan potassium | 5.6 ± 4.0 | 2.5 |
| Samixogrel | 4.2 ± 2.0 | 2.5 |
| AM-103‡,§,ǁ | 4.5 ± 2.6 | 2.5 |
| ODM-103‡,ǁ | 9.0 ± 2.2 | 2.5 |
| ON-09310 | 5.9 ± 1.7 | 2.5 |
| P-7435‡ | NA# | 2.5 |
| AZD-4769 | 2.5 ± 0.9 | 2.5 |
| Calcimycin | 2.1 ± 0.1 | 2.5 |
| Vadadustat‡ | 7.9 ± 6.3 | 2.5 |
| Metabromsalan‡ | 8.0 ± 2.5 | 2.5 |
| IMD-0560 | 2.3 ± 1.1 | 2.5 |
| Laflunimus | 7.2 ± 3.7 | 2.5 |
NA, not applicable.
*Concentration that produces 50% inhibition.
†Lowest concentration of statistically significant inhibition.
‡LIC is antisickling for cells from two of three donors.
§Compound causes lysis at high concentration, antisickling at lower concentration.
¶Incubated for 8 h.
#IC50s could not be determined for these three compounds because of an insufficient number of data points higher than 0% inhibition.
ǁIC50s could only be determined for two of the three donor samples for these compounds because of an insufficient number of data points higher than 0% inhibition.
**IC50s could only be determined for one of the donor samples for these compounds because of an insufficient number of data points higher than 0% inhibition.