Fig. 2.

The structure of TMEM95 is homologous to IZUMO1. (A) Overlay of ribbon and space-filling diagrams of TMEM95 with structural elements labeled. (B) Ribbon diagram of TMEM95 with disulfide linkages labeled in yellow texts (same in IZUMO1) or red texts (different in IZUMO1). Domain organizations of (C) TMEM95 and (D) IZUMO1 with cysteine positions labeled as yellow dots and disulfide linked in black (same in TMEM95 and IZUMO1) or red lines (different between TMEM95 and IZUMO1). TMEM95 shows homology to the N terminus of IZUMO1 (SI Appendix, Fig. S2).