Fig. 5.

Siponimod ameliorates cuprizone-induced pathologies in Rag1^−/− mice. (A) Representative LFB/PAS, anti-IBA1, and anti-APP A4 stains of the medial CC from control (n = 3), Cup3wks-Veh (n = 5) and Cup3wks-Sipo (n = 5) Rag1^−/− mice. (B) Evaluation of the extent of demyelination (LFB/PAS), microgliosis (anti-IBA1), acute axonal injury (anti-APP A4) and pan-oligodendrocyte densities (anti-OLIG2). Statistical analyzes were performed by Mann–Whitney test between the Cup3wks-Veh and Cup3wks-Sipo groups. Data are shown as mean ± SEM. *P < 0.05.