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. 2022 Sep 26;119(40):e2204509119. doi: 10.1073/pnas.2204509119

Fig. 7.

Fig. 7.

Siponimod ameliorates cuprizone-induced oligodendrocyte degeneration. (A) Quantification of apoptotic cells in H&E (Left) or anti-ATF3 (Right) stained sections of control (n = 3), Cup1wk-Veh (n = 6) and Cup1wk-Sipo (n = 6) mice. Statistical analyzes were performed by Mann–Whitney test as indicated. (C and D) Relative Ccl2 and Cxcl10 mRNA expression levels in the forebrain from control, Cup1wk -vehicle (n = 4), and Cup1wk-siponimod (n = 4) mice. Statistical analyzes were performed by Mann–Whitney test as indicated. Data are shown as mean ± SEM. *P < 0.05; **P < 0.01.