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. 2022 Sep 30;119(40):e2208844119. doi: 10.1073/pnas.2208844119

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Copyright © 2022 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 1. — FGFR4 inhibition is not sufficient to trigger cell death in HuH-7 or JHH-7. (A) CETSA for in-cell target engagement by selective FGFR4 inhibitors. Western blots showing thermostable FGFR4 following heat shock at indicated temperatures in HuH-7 and JHH-7 cells treated with vehicle (DMSO), BLU-554 (1 μM), or FGF-401 (1 μM) for 12 h. (B) CETSA and PARP1 cleavage in HuH-7 and JHH-7 cells treated with indicated concentrations of BLU-554 or FGF-401 for 12 (CETSA) or 48 h (PARP1 cleavage). (C) Crystal violet staining of HuH-7 and JHH-7 cells treated with indicated concentrations of BLU-554 or FGF-401 for 6 d.