Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Sep 30;119(40):e2208844119. doi: 10.1073/pnas.2208844119

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

PMC Copyright notice

Fig. 3. — KLB associates with multiple FGFRs to mediate FGF19 signaling. (A) Coimmunoprecipitation of FGFR1, FGFR3, and FGFR4 with KLB-3×FLAG in HuH-7, JHH-7, and FU97 cells. (B) A cartoon model of the FGF19-FGFR-KLB complex with indicated mutations introduced to perturb complex formation. (C) Effects of indicated KLB mutations on the coimmunoprecipitation of FGFR1, FGFR3, and FGFR4 with KLB-3×FLAG in HuH-7 and JHH-7 cells. (D) Effects of indicated KLB mutations on the viability of HuH-7 and JHH-7 cells after CRISPR inactivation of endogenous KLB. WT, wild type.