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. 2022 Sep 30;119(40):e2208844119. doi: 10.1073/pnas.2208844119

Fig. 4.

Fig. 4.

Inactivation of FGFR3 sensitizes HuH-7 and JHH-7 cells to selective FGFR4 inhibitors (FGFR4i). (A) Scatterplot depicting log2-transformed average fold change (FC) of sgRNA abundance (BLU-554 divided by DMSO) and log10-transformed P value computed by MaGeCK. (B) Viability effects after CRISPR inactivation of FGFR3 in HuH-7 and JHH-7 cells in the presence of vehicle (DMSO), BLU-554 (50 nM), or FGF-401 (10 nM). (C) Measurements of IC50 of FGFR inhibitors on the viability of HuH-7, JHH-7, and FU97 cells. Cells were treated with indicated concentrations of FGFR inhibitors for 3 (HuH-7 and JHH-7) and 6 d (FU97) before viability assessment.