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. 2022 May 23;40(10):1520–1527. doi: 10.1038/s41587-022-01307-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — (a) Alphabet used to represent normal and methylated base pairs. (b) Same as Extended Data Figure 2a, but showing the combinations of ATF4, CEBPγ, and normal and methylated DNA that were included in each experiment and the resulting complexes that were modeled. (c) K-mer enrichment analysis for the observed ATF4 EpiSELEX-seq read counts (left), the counts predicted by a mononucleotide-only model (middle), and the counts predicted by a mono- and di-nucleotide model (right). Each scatterplot compares the 8-mer enrichment observed in the normal (x-axis) and methylated (y-axis) libraries. Every point represents an 8-mer and is colored according to the legend; color is assigned based on a 6bp matching substring between the 8mer and the IUPAC code.