Table 1.

Distribution of alleles in single cell-derived clones edited at MTOR by co-selection

MTOR mutation	% of clones with indicated alleles
	WT	WT + large insertion(s)	Monoallelic PE*	Biallelic	Triallelic
				PE*	PE&
E2419K	0% (0/30)	0% (0/30)	40% (12/30)	33% (10/30)	27% (8/30)
F2108L	0% (0/31)	6% (2/31)	26% (8/31)	19% (6/31)	48% (15/31)
I2017T	4% (1/27)	11% (3/27)	37% (10/27)	22% (6/27)	26% (7/27)
Total	1% (1/88)	6% (5/88)	34% (30/88)	25% (22/88)	34% (30/88)

Compilation of genotypes from Supplementary Fig. 14.

^*Except for two MTOR-F2108L clones, all remaining alleles harbor small indels, large insertions and deletions, or pegRNA scaffold incorporation (See Supplementary Fig. 14).

^&Homozygous, only PE-specified sequences are detected.