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. 2022 Oct 7;12:16899. doi: 10.1038/s41598-022-21345-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Overexpression of CAMSAP2 promoted migration and invasion in colorectal cancer cells. (A) qRT-PCR analysis of CAMSAP2 mRNA in SW-620 and SW-480 cells transduced with CAMSAP2 plasmid (CAMSAP2) or control plasmid (Vector). (B) Immunoblotting analysis validated that CAMSAP2 was overexpressed in SW-620 and SW-480 cells transduced with CAMSAP2 plasmid. (C) Wound healing assay showed overexpression of CAMSAP2 enhanced cell migration in colorectal cancer cells. Left: representative images of wound scratch. Right: histograms represent the analysis of the wound healing rate. Scale bar: 100 μm. (D) Overexpression of CAMSAP2 promoted the migration of colorectal cancer cells examined by transwell migration assay. Scale bar: 100 μm. (E) Transwell invasion assay showed that overexpression of CAMSAP2 promoted the invasion in SW-620 and SW-480 cells. Scale bar: 100 μm. (F) Enforced overexpression of CAMSAP2 promoted the lung metastasis in colorectal cancer. Scale bar: 500 μm. **P < 0.01; ***P < 0.001.