Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Oct 7;5:1066. doi: 10.1038/s42003-022-03975-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 5 — a Heatmap showing the 14 integrative molecular modules for each ligand at 24H and 48H. Features are grouped by cluster. Biological interpretation for modules is indicated on the left; feature callouts for RPPA (R), CyCIF (C), ATACseq (A) are shown to the right. b Bubble plot shows the top enriched Reactome pathways in each module, computed from RNAseq features. Dot size indicates the gene ratio; dot color indicates FDR value. c Heatmap showing the five top-ranked ChEA3 transcription factor enrichments computed from the RNAseq features in each module (pink). Red border indicates transcription factor enrichments with a q-value below 0.2 (FDR-adjusted Fisher’s exact test). d–g Scatterplots show the relationships between module activity and quantitative phenotypic responses for selected pairs. Dot color indicates the ligand treatment and dot size indicates the time point. The black dotted line shows the linear fit, and the q-value of the fit is shown at the bottom of the plot.