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. 2022 Oct 7;12:16846. doi: 10.1038/s41598-022-20404-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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DIAMOnD methodology. The network corresponds to the human interactome where the orange circular nodes are the seed proteins, the green square node is the protein to test with k connections (red and grey thick links) including k_s links to seed proteins (red thick links), the grey circular nodes refer to other proteins in the interactome. The ensembles considered in the hypergeometric test for the computation of connectivity significance are reported.