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. 2022 Sep 13;47(11):3476–3489. doi: 10.1007/s11064-022-03710-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — SCFAs inhibited the expression of IL-6 and NLRP3 in astrocytes after OGD in vitro. Immunofluorescence images show the expression of GFAP (A, D, G, green), IL-6 (B, E, H, red). The co-localized expression of GFAP and IL-6 can be seen in panels C, F, I. Panel J shows NLRP3 (62 kDa), IL-6 (23 kDa), and â-actin (42 kDa) immunoreactive bands. Bar graphs in K and L show significant increases in the optical density of NLRP3 and IL-6 at 1 h after OGD administration when compared with the corresponding controls. The SCFAs antagonist may attenuate the increment