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. 2022 Oct 7;12:437. doi: 10.1038/s41398-022-02176-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Minimum free energy (MFE) secondary structure prediction of A miR-499a wild-type and rs140486571 (G/A); B miR-2113 wild-type and rs142927919 (G/A) and C miR-1908 wild-type and rs174561 (A/G) sequences. The positions of the variant nucleotides are indicated by black circles. Regions of the mature miRNAs are highlighted in colour (green for 3p, red for 5p). Drosha cleavage sites on both strands are indicated by scissors.