Table 4. Top characterized OASS chemical inhibitors.

Inhibitor	Enzyme	IC50 (µM)*	KD (µM)*	Citation
Cyclopropyl derivative 7 (UPAR40)	HiCysK	700 ± 53	1.46 ± 0.25	[114]
Cyclopropyl derivative 17		ND	1.45†	[117]
Cyclopropane carboxylic acid 14b (UPAR415)	StCysK	ND	0.028 ± 0.005	[117]
	StCysM	ND	0.49 ± 0.05	[117]
Cyclopropane carboxylic acid 15b	StCysK	0.099 ± 0.004	0.054 ± 0.008	[117]
	StCysM	0.50 ± 0.03	0.42 ± 0.06	[117]
8a	StCysK	ND	–	[123]
	StCysM	ND	–	[123]
9e	StCysK	ND	0.035 ± 0.003	[123]
	StCysM	ND	0.61 ± 0.08	[123]
9f	StCysK	ND	0.051 ± 0.004	[123]
	StCysM	ND	1.45 ± 0.31	[123]
12h	StCysK	ND	–	[123]
	StCysM	ND	–	[123]
13h	StCysK	ND	0.066 ± 0.005	[123]
	StCysM	ND	3.37 ± 0.72	[123]
21i	StCysK	ND	0.45 ± 0.09	[123]
	StCysM	ND	83.8 ± 16.1	[123]
21j	StCysK	ND	0.25 ± 0.06	[123]
	StCysM	ND	23.6 ± 4.5	[123]
Trifluoroalanine	StCysK	130 ± 10	ND	[122]
	StCysM	1290 ± 230	ND	[122]
Benzoic acid 87	MtbCysK1	0.019 ± 0.0011	ND	[121]
Benzoic acid 1	MtbCysM	ND	0.32 ± 0.01	[7]
Benzoic acid 2	MtbCysK2	ND	22.6 ± 2.4	[7]

ND = not determined.

^*Error reported as standard error.

^†No error reported.