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. 2022 Oct 6;85:104300. doi: 10.1016/j.ebiom.2022.104300

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Overall survival analysis of clinically relevant sub-groups of patients stratified by the NCL expression (cut-off 0.838) in the MultiPlatform786 dataset. Kaplan-Meier curves show overall survival of NB patients with high or low NCL expression. NCL expression cut-off of 0.838 was determined with the elbow method. Expression values were z-scored. Plots are relative to (a) high-risk patients older than 18 months with INSS stage 4tumour, (b) INSS stage 4 patients, (c) age at diagnosis greater than 18 months, (d) age at diagnosis lower than 18 months, (e) stage 1, 2, 3 and 4s patients, (f) MYCNamplified tumours, (g) MYCN non amplified tumours. Plots are entitled with the characteristics of the patients in the sub-population. Survival curves were compared by log-rank test. Number of patients with low or high NCL expressions (brackets) and those who succumbed to disease (square brackets) are reported. Each plot reports the hazard ratio (HR) and 95% confidence interval (CI). The number of subjects at risk is displayed under the Kaplan–Meier plots.