Fig. 2. General overview of some aspects of mitochondrial dysfunction in metabolic associated liver disease as described in the text, diagram adapted from Wu et al.20.

Aerobic respiration with ATP synthase highlighted as essential co-factor in oxidative phosphorylation in making ATP. Fis1 is an outer mitochondrial membrane protein that interacts with DRP1 to initiate fission and damaged mitochondria purged by mitophagy. Healthy mitochondria fuse to continue network facilitated by MFN1/2.