REAGENT or RESOURCE	SOURCE	IDENTIFIER
Biological samples
APTK murine organoids	This study	NA
APTKA murine organoids	This study	NA
Chemicals, peptides, and recombinant proteins
Cultrex Reduced Growth Factor Basement Membrane Extract, Type 2	R&D Systems	Cat# 3533-010-02
Corning® Matrigel® Growth Factor Reduced (GFR)	Corning	Cat# 356231
GlutaMAX	Thermo Fisher Scientific	Cat# 35050061
HEPES	Thermo Fisher Scientific	Cat# 15630080
Penicillin/ Streptomycin	Thermo Fisher Scientific	Cat# 15070063
B-27 supplement	Thermo Fisher Scientific	Cat# 12587010
N-2 supplement	Thermo Fisher Scientific	Cat# 17502048
N-Acetyl-L-cysteine	Sigma-Aldrich	Cat# A9165
Advanced DMEM/F-12	Thermo Fisher Scientific	Cat# 12634028
Hygromycin B	Thermo Fisher Scientific	Cat# 10687010
Puromycin dihydrochloride	Merck	Cat# 58-58-2
Dextran Sulfate Sodium (DSS)	MP Biomedicals	Cat# 216011090
Cell recovery solution	Corning	Cat# 354253
Accutase cell dissociation reagent	Thermo Fisher Scientific	Cat# A1110501
Ketamine (10%)	Serumwerk Bernburg (Bernburg)	Cat# 13690.00.00
Xylazine	Serumwerk Bernburg (Bernburg)	Cat# 3100265.00.00
Isoflurane	Zoetis	Cat# TU 061220
Vaseline	Sigma-Aldrich	Cat# 16415
Experimental models: Organisms/strains
Mouse C57BL/6J (wild type, male and female, 8 weeks-old)	JANVIER LABS	RRID:IMSR_JAX:000664
Software and algorithms
Built-in Muriplan Software (Small Animal Radiation Research Platform)	Xstrahl, Surrey, UK	NA
Other
Plastic Feeding Tubes	Instech Laboratories, Inc	Cat# FTP-18-38-50