Figure 1.

The models were successfully established, and the m6A methyltransferase METTL3 was identified in murine fungal keratitis. (A) Slit-lamp observation of the corneas at 1, 3, 5, and 7 days post-infection. (B) Clinical scores showing that inflammation peaked on day 5. (C) The m6A content in total RNAs in both groups. (D) METTL3 expression was noticeably increased in mouse fungal keratitis, as shown by RT–PCR analysis. (E, F) METTL3 protein levels were assessed via Western blotting. (G) Immunofluorescence was performed to determine METTL3 levels; n = 6; *P < 0.05, **P < 0.01, ***P < 0.001. The scale bar indicates 70 µm.