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Pharmacokinetic Parameters and CVVHDF CL of Cefiderocol and Sulbactam
| Parameter | Cefiderocol 2g q8 (3-h Infusion) | Sulbactam 3g q8a (4-h Infusion) |
|---|---|---|
| Vd, L | 33.80 | 33.36 |
| K10, h−1 | 0.10 | 0.16 |
| Half-life, h | 6.80 | 4.27 |
| Cmax, mg/L | 50.10 | 66.15 |
| CL, L/h | 3.40 | 5.41 |
| CLCVVHDF, L/h | 3.53 | 3.72 |
Abbreviations: CL, clearance; CVVHDF, continuous venovenous hemodiafiltration.
Administered as ampicillin 6 g/sulbactam 3 g given every 8 h via a 4-h infusion.
