Fig. 3.

Patterns of extended haplotype homozygosity (EHH) in the pooled Ethiopian Semitic/Cushitic population and global allele frequency variation at nonsynonymous SNPs showing strong positive selection signals: ADH1B*48His (a–c), rs1573496 (ADH7) (d–f), and rs113337987 (MTTP) (g–i). For all three panels, the left-most figure shows the extent of haplotype homozygosity for the derived and ancestral alleles (a, d, g). In the next figure to the right, each row is a haplotype grouped by whether it carries the derived or ancestral allele. For each site along a haplotype, adjacent haplotypes of the same color are identical in sequence between that site and the central (selected) site (b, e, h). Right-most figures show global and Northeast Africa-specific allele frequencies (c, f, i). Abbreviations denote language family: S, Afroasiatic Semitic; C, Afroasiatic Cushitic; O, Afroasiatic Omotic; NS, Nilo-Saharan.