Fig. 6.

Patterns of local ancestry at the alcohol dehydrogenase gene region in the pooled Ethiopian Semitic/Cushitic population. (a) Histogram showing the proportion of haplotypes inferred to be “non-African” at each SNP genome-wide. Compared with the rest of the genome, the rs1229984 site (which contains the ADH1B*48His allele, blue vertical line) is at the tail-end of the empirical distribution for the proportion of haplotypes in the population inferred to be non-African, suggesting positive selection post-admixture. In contrast, the rs1573496 (ADH7) and rs113337987 (MTTP) sites (orange vertical lines) are not at the tail-end of the empirical distribution. (b) RFmix local ancestry results. Each row is a haplotype, and the color of the haplotype represents African (purple) or non-African (yellow) ancestry inferred at each position along the haplotype. Haplotypes carrying the ADH1B*48His allele are almost entirely inferred to be non-African in origin at the ADH region.