Table 1.
All exonic variants within 2 Mb of ADH1B*48His showing the strongest positive selection signals in the pooled Ethiopian Semitic/Cushitic population.
| Chr | Position (hg19) | |iHS| (pval) | Di (pval) | Ancestral | Derived | Gene | Function | rsID | R 2 with ADH1B*48His | D′ with ADH1B*48His |
|---|---|---|---|---|---|---|---|---|---|---|
| 4 | 100518283 | 4.5994 (0.00003) | 39.9182 (0.00573) | C | T | MTTP | Synonymous SNV | rs17533489 | 0.414032 | 0.673279 |
| 4 | 100532602 | 4.17267 (0.00012) | 65.137 (0.00057) | G | A | MTTP | Nonsynonymous SNV | rs113337987 | 0.492046 | 0.716041 |
| 4 | 100512849 | 3.87698 (0.00028) | 64.137 (0.00056) | T | C | MTTP | Synonymous SNV | rs113557405 | 0.492046 | 0.716041 |
| 4 | 100239319 | 3.24222 (0.00162) | 69.0986 (0.00036) | C | T | ADH1B | Nonsynonymous SNV | rs1229984 | - | - |
| 4 | 100349669 | 3.08308 (0.00252) | 45.8996 (0.00319) | C | G | ADH7 | Nonsynonymous SNV | rs1573496 | 0.429619 | 0.789771 |
| 4 | 100140306 | 3.04377 (0.00283) | 17.8031 (0.05335) | T | A | ADH6 | Nonsynonymous SNV | rs4699735 | 0.0600005 | 1 |
| 4 | 100263965 | 2.74795 (0.00651) | 11.4911 (0.10432) | C | T | ADH1C | Nonsynonymous SNV | rs1693482 | 0.0643213 | 1 |
| 4 | 100516022 | 2.71836 (0.00705) | −9.16196 (0.85818) | G | C | MTTP | Nonsynonymous SNV | rs2306985 | 0.100461 | 0.72245 |
| 4 | 100510859 | 2.54494 (0.01135) | −9.21845 (0.86125) | C | T | MTTP | Synonymous SNV | rs991811 | 0.103183 | 0.728042 |
| 4 | 100485255 | 2.53289 (0.01173) | 7.71301 (0.16029) | G | A | MTTP | Startloss | rs11944752 | 0.20251 | 0.652898 |
| 4 | 100341861 | 2.49383 (0.01304) | 25.2181 (0.02502) | C | T | ADH7 | Synonymous SNV | rs971074 | 0.442753 | 0.682467 |
| 4 | 100443720 | 2.48587 (0.01333) | 1.69391 (0.3495) | G | A | C4orf17 | Nonsynonymous SNV | rs13143848 | 0.0645508 | 0.625067 |
| 4 | 100504664 | 2.43168 (0.01534) | 8.04044 (0.15411) | T | C | MTTP | Nonsynonymous SNV | rs3816873 | 0.20251 | 0.652898 |
| 4 | 99993833 | 2.33428 (0.01980) | −1.23324 (0.49645) | A | G | ADH5 | Synonymous SNV | rs28730643 | 0.0657764 | 1 |
| 4 | 100266371 | 2.31467 (0.02083) | 7.28774 (0.16868) | A | G | ADH1C | Synonymous SNV | rs1789915 | 0.0487944 | 1 |
| 4 | 100512412 | 2.19513 (0.02814) | 25.6785 (0.0239) | T | C | MTTP | Synonymous SNV | rs982424 | 0.0500503 | 0.802629 |
| 4 | 100235053 | 2.16861 (0.03003) | 0.54593 (0.40685) | G | A | ADH1B | Synonymous SNV | rs1789882 | 0.0501706 | 1 |
| 4 | 100266112 | 1.97141 (0.04823) | 11.4911 (0.10432) | C | T | ADH1C | Synonymous SNV | rs1693425 | 0.0643213 | 1 |
Note.—Nonsynonymous mutations showing particularly strong selection signals that are examined in detail in main text are bolded.